Many trees confuse these 2 Mary's. All the children listed in his will came from his 2nd wife.
"Will of John Parham, Elbert Co., GA, signed Aug 2, 1804, registered Apr 22, 1805. I give estate to wife, Mary, for life. At her death to my several children, viz: Elizabeth Bennett, Cannon Parham, John Parham, Isam Parham, Nancy Sargent, Mary Upshaw, Thomas Parham, Holeberry Hicks, Mildred Parham, Dickson Parham, Frances Parham and Lucy Parham. My estate consists of a small tract of land on Dove's Creek on which I live, six Negroes,, small stock of horses, etc. Sons, John and Isom and friend William Davis, Executors. Witnesses, David Hicks, Edmond Shackleford and Thomas Parham."
http://trees.ancestry.com/tree/6275091/person/-743556389/story/2c82c308-32b2-491b-b1fc-0b544d6cde36