Ruminations

Behind the screen

Author: Kyle

  • 16. Conclusion

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    Kyle
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    Just Don’t Get Hit By A Bus This book opened with a clock about to strike midnight. The biological clock running inside each of us does not measure time in hours but in hallmarks. Twelve of them, identified by López-Otín and colleagues and updated in 2023: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis,…

  • Appendix B: What I Take

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    I do not try to find the cheapest supplements but rather the ones that are best formulated to work. For that reason, most of the supplements I take now are from the Life Extension company. (The company was formerly the Life Extension Foundation, so I will stick with the abbreviation, LEF.) The supplements they provide…

  • References

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    Foundational Books Pauling L. Vitamin C and the Common Cold. San Francisco: W.H. Freeman; 1970. Stone I. The Healing Factor: Vitamin C Against Disease. New York: Grossman Publishers; 1972. Passwater RA. Supernutrition: Megavitamin Revolution. New York: Dial Press; 1975. Passwater RA. Super-Nutrition for Healthy Hearts. New York: Dial Press; 1977. Pauling L. Cancer and Vitamin…

  • 15. Future Longevity Advances

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    What Is Coming and When Consider what medicine looked like in 1926. No antibiotics. No understanding of DNA. No molecular virology. No vaccines for polio or measles. Cancer treated primarily by surgery. Diabetes a death sentence for most of human history, with insulin barely four years in clinical use. Heart surgery impossible. Average American lifespan:…

  • 14. The Philosophy of Immortality

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    What it means to Live Forever “There is no reason to suppose that a man whose hair is grey and whose face is wrinkled has lived a long life — he has merely existed for a long time.” — Seneca, quoted in Stanisław Lem’s 1959 novel on AI and information control The supplements work. The…

  • Translation Key

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    Kyle
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    Terms and Abbreviations used in How To Live Forever ABA Design (Reversal Design) — a single-subject experimental methodology used in behavioral science. Whenever trying a novel intervention, try to “take it, stop taking it, take it again” so the supplement is the only variable. ALCAR — Acetyl-L-Carnitine. An amino acid derivative that shuttles fatty acids…

  • Chapter 12: Combining Interventions

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    The Whole Is Greater Than the Sum The Annual Increment chapter documented compounds with individually verified lifespan extension data, organized by the quality of the evidence behind them. It ended with a provocation: add the bold percentages and you get 317%. Multiply the average American lifespan by 3.17 and you get 253 years. The number…

  • The Tilted Playing Field

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    Kyle
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    American Producers Were Set Up To Lose Part of the “To Boldly Go” Austrian Economics Series The trade war debate produces a lot of heat and very little light — mostly because it focuses on the wrong variable. The standard analysis compares Chinese wages to American wages, finds a large gap, and concludes that the…

  • Preface

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    Kyle
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    The aging clock above shows the twelve hallmarks of aging identified by López-Otín and colleagues — the molecular processes now understood to drive visible aging. My Quest I am not going to tell you to eat less and exercise more — you already know that. This book is about what comes after. It is primarily…

  • 9. The Sleep Protocol

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    You’re Missing The Best Part Talk to anyone over sixty about sleep. The conversation is remarkably consistent: difficulty falling asleep, waking at 3 or 4AM unable to return to sleep, lying awake for hours while the mind races through the previous day’s unresolved concerns. The anecdote is confirmed at population scale; a meta-analysis of 252…